[HTML][HTML] Cytotoxicity of δ-tocotrienols from Kielmeyera coriacea against cancer cell lines
ML de Mesquita, RM Araújo, DP Bezerra… - Bioorganic & medicinal …, 2011 - Elsevier
In the search for new anti-cancer compounds, Brazilian Cerrado plant species have been
investigated. The hexane root bark extract of Kielmeyera coriacea lead to a mixture of δ-
tocotrienol (1) and its dimer (2). The structures of both compounds 1 and 2 were established
based on detailed 1D and 2D NMR and EI-MS analyses. The cytotoxicity of the mixture was
tested against four human tumor cell lines in the following cultures: MDA-MB-435
(melanoma), HCT-8 (colon), HL-60 (leukemia), and SF-295 (glioblastoma), and displayed …
investigated. The hexane root bark extract of Kielmeyera coriacea lead to a mixture of δ-
tocotrienol (1) and its dimer (2). The structures of both compounds 1 and 2 were established
based on detailed 1D and 2D NMR and EI-MS analyses. The cytotoxicity of the mixture was
tested against four human tumor cell lines in the following cultures: MDA-MB-435
(melanoma), HCT-8 (colon), HL-60 (leukemia), and SF-295 (glioblastoma), and displayed …
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